In the 2008 version of the PREX database, the AhpC-Prx1 subfamily was divided into four groups. General information about the AhpC-Prx1 subfamily is available here.
Group 1 is the largest group and contains almost all the eukaryotic members of the Prx subfamily along with a similar number of bacterial proteins. Characterized members of this subgroup are reduced by thioredoxin (Trx) (Poole 2005) or by an organism-specific reductant such as tryparedoxin (Krauth-Siegel and Comini 2008) or the glutaredoxin-like Cp9 in Clostridium pasteurianum (Reynolds et al. 2002).
| PDB identifiers | Name | Species |
|---|---|---|
| 1e2y | tryparedoxin peroxidase | Crithidia fasciculata |
| 1qmv | Prx2 | Homo sapiens |
| 1qq2, 2z9s | Prx1 | Rattus norvegicus |
| 1uul | tryparedoxin peroxidase | Trypanosoma cruzi |
| 1zof | AhpC | Helicobacter pylori |
| 1zye | Prx3 | Bos taurus |
| 2h01 | thiol peroxidase 1 | Plasmodium yoelli |
| 2c0d | Mitochondrial 2-Cys Prx | Plasmodium falciparum |
| 2pn8 | Prx4 | Homo sapiens |
| 2rii, 2hy2 | Prx1 (complex with Srx) | Homo sapiens |
| 2h66, 2i81 | 2-Cys | Plasmodium vivax |
Group 2 is predominantly bacterial (with some archaeal representatives) and contains the canonical AhpC proteins. Members of group 2 include Salmonella typhimurium AhpC, E. coli AhpC, Treponema pallidum AhpC, and Amphibacillus xylanus AhpC. Based on presence of an ahpF gene in the ahpC operon, all AhpC/Prx1 subfamily members reduced by an AhpF protein are found in group 2 (Poole 2005).
| PDB identifiers | Name | Species |
|---|---|---|
| 1yep, 1n8j, 1yex, 1yfo, 1yf1, 3emp | AhpC | Salmonella typhimurium |
| 1we0 | AhpC | Amphibacillus xylanus |
Group 3 is exclusively bacterial and contains Prxs from Mycobacterium, Bordetella, and Streptomyces species. All of the AhpC-like proteins associated with an AhpD (determined based on presence of an ahpD gene in the ahpC operon) are found in group 3.
| PDB identifier | Name | Species |
|---|---|---|
| 2bmx | AhpC | Mycobacterium tuberculosis |
Group 4 is exclusively bacterial, comprised of proteins from the genera Flavobacteria and Chlamydia. None of the members of this subgroup have been characterized to date.