Laboratory of Thomas Hollis

Structural Biology of DNA Repair

The maintenance of DNA integrity is essential for normal cellular function and for the propagation of the genetic code to successive generations. A variety of endogenous cellular reagents and exogenous toxins are capable of reacting with and modifying DNA. These modifications can pose blocks to replicative DNA polymerases and/or interfere with the binding of regulatory proteins to DNA causing wide spread cellular responses. Repair of lesions in DNA is a critical cellular response mediated by enzymes that can accurately detect, remove and/or correct the damaged bases. Research in the Hollis laboratory focuses on the structural biology of proteins involved in DNA repair. We use a combination of X-ray crystallography, biochemistry and molecular biology to address questions of DNA damage recognition and repair by proteins.

Hollis Lab News

05/2013 Congratulations to Lindsey Remington for being awarded the Wake Forest Research Fellowship


09/04/12 Congratulations Dr. Annie Huhn for successfully defending your thesis!!


07/2012 Congratulations Chris Mauney for being awarded support by the NIH training grant in Structural and Computational Biophysics (SCB)


06/2012 Welcome Lindsey Remington
Lindsey is a WFU undergraduate student joining us in the lab

04/2012 Welcome Chris Mauney
Chris is a new graduate student joining the lab

10/2010: Congratulations to Eddie Pryor and Annie Huhn
Graduate students Eddie Pryor and Annie Huhn received departmental awards. Eddie received the Herbert Cheung Award for outstanding senior graduate student, and Annie received the Cowgill fellowship.

8/2010: Congratulations Eddie on your Student Traineeship Award from the Cystic Fibrosis Foundation

4/2010: Congratulations Nadine Shaban on your Student Travel Award to present at the ASBMB meeting in Anaheim, CA

Thomas Hollis, PhD, Associate Professor
Department of Biochemistry and Center for Structural Biology
Wake Forest University School of Medicine
Medical Center Blvd
Winston-Salem, NC 27157
Tel (336) 716.0768
Fax (336) 777.3242
Email: thollis@wfubmc.edu,